Disease X: Preparing for the Unknown
3 min read
In a world where the threat of new diseases is ever-present, the scientific community is monitoring what has been termed Disease X. This disease is a hypothetical pathogen that may lead to a serious international epidemic if not contained. This article explores the concept of Disease X, the efforts of the World Health Organization (WHO) in prioritizing diseases for research and development, and how scientists are preparing in case there’s a health threat.
What to Know About Disease X
Disease X is a term coined by the World Health Organization (WHO). The concept of Disease X is part of the WHO’s Research and Development (R&D) Blueprint, which is a strategy to improve emergency preparedness. It ensures that R&D efforts are focused and productive, particularly for diseases that pose the greatest public health risk due to their epidemic potential and for which there are no or insufficient countermeasures.

The WHO’s Role in Preparing for Disease X
Planning strategies around Disease X ensures that the WHO, along with its partners, remains vigilant and ready to mobilize R&D efforts swiftly in the face of unforeseen threats. This forward-thinking approach aims to establish flexible and robust systems that can adapt to new challenges, potentially saving millions of lives by preventing global health crises before they can begin.
Through this blueprint, the WHO aims to streamline the process of developing diagnostics, vaccines, and treatments for known diseases. At the same it, it plans to create a framework that other health institutions can quickly implement for unknown pathogens that may emerge in the future.
The WHO’s Priority Pathogen List
The World Health Organization’s Priority Pathogen List is a catalog of bacteria, viruses, and other pathogens that pose a significant risk to human health, particularly due to their potential to cause epidemics and the lack of effective drugs or vaccines against them. The list is designed to guide and promote the R&D of new and improved medical countermeasures like medications and health protocols.
Some of the diseases included in the list are the following:
- Ebola
- Zika virus
- Lassa fever
- COVID-19
- MERS-CoV
The Role of Scientists in Pathogen Identification
WHO is actively working to identify pathogens that could cause future outbreaks and pandemics. This process involves a global collaboration of scientists who evaluate evidence on various virus families and bacteria.

Scientists consider over 25 virus families and bacteria, including Disease X. They recommend which pathogens need further research and investment. Aside from these, they are in charge of the following:
- Surveillance. Scientists monitor and collect data on emerging and existing pathogens, often working within public health frameworks to track the spread of diseases.
- Research. They conduct studies to understand the biology, transmission, and impact of pathogens. This includes studying their genetic makeup, life cycle, and how they interact with hosts.
- Development of Diagnostic Tools. Scientists develop tests and procedures to detect pathogens in individuals and populations. Accurate diagnostics are essential for effective treatment and containment of diseases.
- Vaccine and Treatment Research. They also work on the development of vaccines and treatments. Understanding the pathogen is the first step in creating targeted therapies to combat infections.
- Risk Assessment. Scientists assess the potential risks posed by pathogens, including their capacity to cause outbreaks or pandemics.
- Public Health Policy. Scientific research findings inform the public about health policy and strategies for disease prevention, containment, and control.
- Education and Communication. Scientists communicate their findings to the public, healthcare professionals, and policymakers. At the same time, they provide best practices for disease prevention and management.
One Health Approach and Environmental Factors
The One Health approach recognizes the interconnectedness of human, animal, and environmental health. It stresses the importance of considering environmental issues and animal health in the context of disease prevention and control.
Furthermore, it supports WHO’s R&D to prevent animal diseases that may spill over to humans. It also enhances food security and minimizes the risk of public health emergencies.

As the scientific community continues to monitor and research priority pathogens, the concept of Disease X serves as a reminder of the unpredictable nature of epidemics. The WHO’s efforts to prioritize diseases and develop strategic R&D plans are critical in safeguarding global health against future threats. Research, investment, and international collaboration must remain at the forefront of our preparedness just in case we face another pandemic.